| Name | Product/Service
| Employees |
|---|
| Higginsville Habilitation Center | Health Care/Special Ed Services | 491 |
| Lafayette County C-1 | School District | 151 |
| Meyer Foundation | Retirement Center/Nursing Home | 146 |
| Wal-Mart | Department Store | 88 |
| WinCup | Styrofoam Insulated Cup Mfg | 78
|
| Pilot Travel Center | Travel Center | 75 |
| City of Higginsville | Municipal Services | 69 |
| Buck’s Country Mart | Grocery Store | 55 |
| United Parcel Service | Freight/Parcel Service | 45 |
| West Central Electric | Electric Distribution (Rural) | 43 |
| McDonald’s | Restaurant | 40 |
| Pizza Hut | Restaurant | 31 |
| Piggly Wiggly | Grocery Store | 26 |
| Heartland Farm & Lawn | Farm Implement Dealer | 25 |
| Family Practice Associates | Medical Services | 21 |
| Citizens Telephone | Telephone Services | 20 |
| Medicine Shoppe | Pharmacy | 15 |
| US Bank | Financial Services | 14 |